Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo

Ulukaya E., ARI F., Dimas K., Ikitimur E. I., Guney E., YILMAZ V. T.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.46, sa.10, ss.4957-4963, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 10
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.ejmech.2011.07.055
  • Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4957-4963
  • Anahtar Kelimeler: Palladium(II) complex, Breast cancer, Cytotoxicity, Apoptosis, Treatment, PLATINUM(II) COMPLEXES, BIOLOGICAL EVALUATION, CYTOTOXIC ACTIVITY, PD(II), PT(II), ASSAY, MTT
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Anti-cancer effects of a newly-synthesized palladium(II) complex, [Pd(sac)(terpy)](sac)center dot 4H(2)O (sac = saccharinate, and terpy = 2,2':6',2 ''-terpyridine), were tested against human breast cancer cell lines, MCF-7 and MDA-MB-231. The Pd complex had a strong anti-growth effect in a dose- and time-dependent manner in vitro. This effect was also confirmed by the experiment performed on Balb/c mice in vivo. The IC50 values were 0.09 mu M for MDA-MB-231 and 3.05 mu M for MCF-7. It was also very effective in disrupting the formation of MDA-MB-231 tubules on matrigel, indicative of a putative anti-invasive activity. It induced apoptosis via the cell death genes of DR4 and DR5. In conclusion, this newly-synthesized Pd (II) complex represents a potentially active novel drug for the breast cancer treatment. (C) 2011 Elsevier Masson SAS. All rights reserved.