Mutation analysis of the PARKIN, PINK1, DJ1, and SNCA genes in Turkish early-onset Parkinson's patients and genotype-phenotype correlations.


Erer S., Egeli Ü., Zarifoğlu M., Tezcan G., Çeçener G., Tunca B., ...Daha Fazla

Clinical neurology and neurosurgery, cilt.148, ss.147-53, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 148
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.clineuro.2016.07.005
  • Dergi Adı: Clinical neurology and neurosurgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.147-53
  • Anahtar Kelimeler: Parkinsonism, PARK loci, PRKN, PINK1, DJ1, SNCA, DISEASE, DJ-1, ASSOCIATION, POPULATION, EUROPE, COHORT
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Objective: Variations in PARK genes (PRKN, PINK1, DJ-1, and SNCA) cause early-onset Parkinson's disease (EOPD) in different populations. In the current study, we aimed to evaluate the frequencies of variations in PARK genes and the effects of these variations on the phenotypes of Turkish EOPD patients.