Mutation analysis of the PARKIN, PINK1, DJ1, and SNCA genes in Turkish early-onset Parkinson's patients and genotype-phenotype correlations.

Erer, ÇİĞDEM; Egeli, ÜNAL; Zarifoğlu, MEHMET; Tezcan, GÜLÇİN; Çeçener, GÜLŞAH; Tunca, BERRİN; Ak, SEÇİL; Dernirdogen, Elif; Kenangil, Gulay; Kaleagasi, Hakan; Doğu, Okan; Saka, Esen; Elibol, Bülent

doi:10.1016/j.clineuro.2016.07.005

Mutation analysis of the PARKIN, PINK1, DJ1, and SNCA genes in Turkish early-onset Parkinson's patients and genotype-phenotype correlations.

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Erer S., Egeli Ü., Zarifoğlu M., Tezcan G., Çeçener G., Tunca B., ...More

Clinical neurology and neurosurgery, vol.148, pp.147-53, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 148
Publication Date: 2016
Doi Number: 10.1016/j.clineuro.2016.07.005
Journal Name: Clinical neurology and neurosurgery
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.147-53
Keywords: Parkinsonism, PARK loci, PRKN, PINK1, DJ1, SNCA, DISEASE, DJ-1, ASSOCIATION, POPULATION, EUROPE, COHORT
Bursa Uludag University Affiliated: Yes

Abstract

Objective: Variations in PARK genes (PRKN, PINK1, DJ-1, and SNCA) cause early-onset Parkinson's disease (EOPD) in different populations. In the current study, we aimed to evaluate the frequencies of variations in PARK genes and the effects of these variations on the phenotypes of Turkish EOPD patients.