Intracerebroventricular choline reverses hypotension induced by acute chemical sympathectomy


Gurun M. S. , Savci V., Ulus I.

JOURNAL OF AUTONOMIC PHARMACOLOGY, vol.17, no.3, pp.155-163, 1997 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 3
  • Publication Date: 1997
  • Doi Number: 10.1046/j.1365-2680.1997.00450.x
  • Title of Journal : JOURNAL OF AUTONOMIC PHARMACOLOGY
  • Page Numbers: pp.155-163

Abstract

1 The effect of centrally administered choline on blood pressure was investigated in rats made hypotensive by chemical sympathectomy. Chemical sympathectomy was produced by intravenous (i.v.) injection of 50 mg kg(-1) of 6-hydroxydopamine (6-OHDA). Intracerebroventricular (i.c.v.) administration of choline (50-150 mu g) 2 h after 6-OHDA treatment increased blood pressure and reversed the hypotension in a dose-dependent mariner without affecting heart rate. The presser response was associated with an increase in plasma vasopressin levels.