Intracerebroventricular choline reverses hypotension induced by acute chemical sympathectomy

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Gurun M. S., Savci V., Ulus I.

JOURNAL OF AUTONOMIC PHARMACOLOGY, vol.17, no.3, pp.155-163, 1997 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 17 Issue: 3
• Publication Date: 1997
• Doi Number: 10.1046/j.1365-2680.1997.00450.x
• Journal Name: JOURNAL OF AUTONOMIC PHARMACOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.155-163
• Bursa Uludag University Affiliated: Yes

Abstract

1 The effect of centrally administered choline on blood pressure was investigated in rats made hypotensive by chemical sympathectomy. Chemical sympathectomy was produced by intravenous (i.v.) injection of 50 mg kg(-1) of 6-hydroxydopamine (6-OHDA). Intracerebroventricular (i.c.v.) administration of choline (50-150 mu g) 2 h after 6-OHDA treatment increased blood pressure and reversed the hypotension in a dose-dependent mariner without affecting heart rate. The presser response was associated with an increase in plasma vasopressin levels.