Intracerebroventricular choline reverses hypotension induced by acute chemical sympathectomy
JOURNAL OF AUTONOMIC PHARMACOLOGY, cilt.17, sa.3, ss.155-163, 1997 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 3
- Basım Tarihi: 1997
- Doi Numarası: 10.1046/j.1365-2680.1997.00450.x
- Dergi Adı: JOURNAL OF AUTONOMIC PHARMACOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.155-163
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
1 The effect of centrally administered choline on blood pressure was investigated in rats made hypotensive by chemical sympathectomy. Chemical sympathectomy was produced by intravenous (i.v.) injection of 50 mg kg(-1) of 6-hydroxydopamine (6-OHDA). Intracerebroventricular (i.c.v.) administration of choline (50-150 mu g) 2 h after 6-OHDA treatment increased blood pressure and reversed the hypotension in a dose-dependent mariner without affecting heart rate. The presser response was associated with an increase in plasma vasopressin levels.