Akademik Veri Yönetim Sistemi
BIHAREAN BIOLOGIST, cilt.19, sa.1, ss.45-51, 2025 (Scopus)
Abstract. In this study, the anthelmintic effects of Rosmarinus officinalis (rosemary) leaf extract and its
polyphenolic constituent, rosmarinic acid, were investigated in mice naturally infected with Aspiculuris
tetraptera. The feces of 90 Balb/c mice, naturally infected with A. tetraptera, were examined using the
fecal flotation method to determine the infection status. Three doses of R. officinalis leaves extract were
examined. Infected mice were divided into six groups. The first group received 250 mg/kg, the second
group received 500 mg/kg, the third group was given 1000 mg/kg of R. officinalis leaves extract, the fourth
group was treated with rosmarinic acid 5 mg/kg, the fifth group with albendazole 10 mg/kg and the sixth
group served as the control, receiving physiological saline. The experimental and control groups were
orally administered for 7 days. On the 8th day, all animals were euthanized, and the number and weight
of parasites obtained from the gastrointestinal tract were counted and measured. Percentages of activity
and p-values were calculated as follows: the efficacy values were 89%, 1399 of albendazole; 8%, 17 of
rosmarinic acid; 25,44% of a 250 mg/kg rosemary dose; 46,54% of a 500 mg/kg rosemary dose and 7,16%
of a 1000 mg/kg rosemary dose what do these numbers reflect. P-values were found to be significant in
the second group, which received a 500 mg/kg dose of rosemary leaf extract (p < 0.05), and remained
insignificant in the third, fourth, and fifth groups (p> 0.05).