The Effects of Fenarimol and Methyl Parathion on Glucose 6-PhosphateDehydrogenase Enzyme Activity in Rats


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ARI F., DERE E., TOSUNOĞLU H., ALİOĞLU İ.

Türkiye Tarımsal Araştırmalar Dergisi, vol.4, no.3, pp.275-280, 2017 (Peer-Reviewed Journal)

Abstract

Abstract: Fenarimol and methyl parathion are pesticides that have been used in agriculture for several years. These

pesticides have significant effects on environmental and human health. Therefore, we investigated the effects of methyl

parathion and fenarimol on glucose 6-phosphate dehydrogenase (EC 1.1.1.49) enzyme activity in rats. The glucose 6-

phosphate dehydrogenase is the first enzyme of the pentose phosphate pathway and it is important in detoxifying reactions

by NADPH generated. In this study, wistar albino rats administrated with methyl parathion (7 mg kg–1) and fenarimol (200

mg kg−1) by intraperitoneally for different periods (2, 4, 8, 16, 32, 64, and 72 h). The glucose 6-phosphate dehydrogenase

enzyme activity was assayed in liver, kidney, brain, and small intestine in male and female rats. The exposure of fenarimol

and methyl parathion caused increase of glucose 6-phosphate dehydrogenase enzyme activity in rat tissues, especially at last

periods. We suggest that this increment of enzyme activity may be the reason of toxic effects of fenarimol and methyl

parathion.