The Effects of Fenarimol and Methyl Parathion on Glucose 6-PhosphateDehydrogenase Enzyme Activity in Rats
Türkiye Tarımsal Araştırmalar Dergisi, vol.4, no.3, pp.275-280, 2017 (TRDizin)
- Publication Type: Article / Article
- Volume: 4 Issue: 3
- Publication Date: 2017
- Doi Number: 10.19159/tutad.310371
- Journal Name: Türkiye Tarımsal Araştırmalar Dergisi
- Journal Indexes: TR DİZİN (ULAKBİM)
- Page Numbers: pp.275-280
- Open Archive Collection: AVESIS Open Access Collection
- Bursa Uludag University Affiliated: Yes
Abstract
Abstract: Fenarimol and methyl parathion are pesticides that have been used in agriculture for several years. These
pesticides have significant effects on environmental and human health. Therefore, we investigated the effects of methyl
parathion and fenarimol on glucose 6-phosphate dehydrogenase (EC 1.1.1.49) enzyme activity in rats. The glucose 6-
phosphate dehydrogenase is the first enzyme of the pentose phosphate pathway and it is important in detoxifying reactions
by NADPH generated. In this study, wistar albino rats administrated with methyl parathion (7 mg kg–1) and fenarimol (200
mg kg−1) by intraperitoneally for different periods (2, 4, 8, 16, 32, 64, and 72 h). The glucose 6-phosphate dehydrogenase
enzyme activity was assayed in liver, kidney, brain, and small intestine in male and female rats. The exposure of fenarimol
and methyl parathion caused increase of glucose 6-phosphate dehydrogenase enzyme activity in rat tissues, especially at last
periods. We suggest that this increment of enzyme activity may be the reason of toxic effects of fenarimol and methyl
parathion.