Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Journal of Medical Sciences, cilt.40, sa.4, ss.418-424, 2020 (Scopus)
© 2020 by Türkiye Klinikleri.Objective: The number of breast augmentations and post-mas-tectomy breast reconstructions have dramatically increased since silicone breast implants were introduced in the past fifty years. However capsular con-traction around silicone implants remains a challenging complication which is the most common reason for revision surgeries in these patients. Applica-tion of acellular dermal matrices (ADM) for prevention and treatment of im-plant-associated complications is performed by many surgeons. Therefore, the effects of Belladerm® (MTF,USA). on capsular contracture by defining the cellular dynamics of wound healing process are searched in this study. Material and Methods: We used 24 female Sprague-Dawley rats and divided the animals into one experimental group and one control group each consist-ing of 12 rats. In the control group, we used Slikongel-filled, smooth-surface implants. In the experimental group, we used the same implants of the control group, but unlike we wrapped the implants preoperatively with an acellular dermal matrix, with Belladerm® After 6 weeks, the implants and the result-ing capsular tissue were removed and examined histologically. In the histopathological evaluation, the following parameters were scored: the intensity of polymorfonuclear and mononuclear leucocytes, and the thickness of synovial metaplasia zone around the implants. Results: Regarding the macro-scopic comparison between the control group and the experimental group, it was demonstrated that implants wrapped with Belladerm had better integrated in the surrounding tissue. When analyzing the histiocyte count, which showed an acute inflammatory response at capsule formation, we could not detect any significant differences (p=0.93). However, there was a significant increase in granulocytes (p=0.26), lymphocytes (p<0.001) and synovial metaplasia zone (p<0.001) in the experimental group. Conclusion: Bimodal inflammatory cellular response is utmost important for capsuler tissue formation. We docu-mented that Belladerm® integrates to the surrounding tissue and is not resorbed by host tissue cells at early stages after implant placement. However, the follow-up period should be longer to search the late effects of capsule formation and immunohistachemical stains are required for more exact results.