Centrally and peripherally injected nesfatin-1-evoked respiratory responses

Ciftci K., Guvenc G., Kasikci E., YALÇIN M.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, vol.267, pp.6-11, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 267
  • Publication Date: 2019
  • Doi Number: 10.1016/j.resp.2019.05.015
  • Journal Name: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.6-11
  • Keywords: Nesfatin-1, Tidal volume, Respiratory rate, Respiratory minute ventilation, Intracerebroventricular, Intravenous, BRAIN, NEURONS, OXYTOCIN, NUCLEUS
  • Bursa Uludag University Affiliated: Yes

Abstract

Nesfatin-1, which is an anorexiogenic peptide, plays a crucial role as a neurotransmitter and/or neuromodulator in the central nervous system for cardiovascular control and energy balance etc. It is expressed abundantly in multiple brain nuclei including central respiratory control areas such as nucleus tractus solitarius, nucleus ambiguous, dorsal vagal complex, dorsal motor nucleus of the vagus nerve, and hypothalamus. To date, no previous studies have been found to report nesfatin-1-evoked respiratory effects. Therefore, the present study was designed to investigate the possible impacts of centrally and/or peripherally injected nesfatin-1 on respiratory parameters in either 12h-fasted or fed-ad libitum rats.