Local anesthetics are widely used in childhood as well as in adults. Adverse reactions to these drugs is an important problem for users. The aim of this study was to determine incidence of immediate allergic reactions to Group II local anesthetics in childhood. Our study group consisted of 144 children aged between 1-16 years. Skin tests for arlicaine (Ultracain®) and prilocaine (Citanest®) were performed by initially by prick and intradermally, respectively. If positive reactions to these two drugs were detected, possible reactions to lidocaine (Aritmal®) and bupivacaine (Marcain®) were also investigated. The prevalence of positive skin tests results were as follows: arlicaine 35 (24.3%), prilocaine 34 (23.6%). Positive cross-reaction was observed to lidocaine, arlicaine, and prilocaine in 15 (10.41%) cases and to lidocaine, arlicaine, prilocaine, and bupivacaine in seven (4.86%) cases. There is evidence to suggest that positive reactions to local anesthetics are more frequent in cases with a history of drug allergy.