Olive leaf extract containing oleuropein modulates the cytotoxic effect of epirubicin on breast cancer cells depending on the cell line

Korkmaz S., SARIMAHMUT M., Ozel M. Z., Ulukaya E.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.41, no.6, pp.385-392, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.1515/tjb-2016-0117
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.385-392
  • Keywords: Olive leaf extract, Breast cancer cell lines, Apoptosis, Cytotoxicity, Epirubicin, MEDITERRANEAN DIET, BITTER PRINCIPLE, IN-VITRO, APOPTOSIS, PHYTOCHEMICALS, COMBINATION, INHIBITION, ACTIVATION, RESISTANCE, RISK
  • Bursa Uludag University Affiliated: Yes

Abstract

Objective: Epidemiologic studies showed that nutrition plays a role in incidence of cancer. However, little is known if nutrition also modulates the effect of chemotherapeutics. For this purpose, the present study investigates the cytotoxic effect of olive leaf extract and its combination with epirubicin.