Effects of vitamin E and cimetidine on peritonitis-induced lipid peroxidation

Tuncel P., Gur E., Kaya E., Ozbek R., Ozturk E., Tokyay R.

RESEARCH IN EXPERIMENTAL MEDICINE, vol.197, no.4, pp.235-241, 1997 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 197 Issue: 4
  • Publication Date: 1997
  • Doi Number: 10.1007/s004330050072
  • Journal Name: RESEARCH IN EXPERIMENTAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.235-241
  • Bursa Uludag University Affiliated: No

Abstract

To investigate the effects of acute fecal peritonitis on plasma and tissue lipid peroxidation and possible protective effects of vitamin E (Vit E) and cimetidine at 4 h in a rat peritonitis model, four groups were designated as: controls, peritonitis, Vit E and cimetidine. Plasma, liver, lung and kidney thiobarbituric acid reactive substances (TBARS) and conjugated diene (CD) levels were measured to monitor oxidative injury. The present fecal peritonitis model caused a significant elevation in liver TBARS; however, neither Vit E nor cimetidine was effective in preventing TBARS formation. Administration of Vit E and cimetidine caused significant decrements from the peritonitis value in liver and lung CD levels.