Impact of Storage Period on CD4(+)/CD8(+) T Lymphocyte Ratio in Erythrocyte Suspensions

Bal S. H., Kumas L. T., HEPER Y., BUDAK F., Goral G., Can F. E., ...More

TURKISH JOURNAL OF IMMUNOLOGY, vol.8, no.2, pp.44-49, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.25002/tji.2020.1242
  • Journal Name: TURKISH JOURNAL OF IMMUNOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.44-49
  • Keywords: CD4-CD8 ratio, erythrocyte suspension, erythrocyte transfusion, immunomodulation, transfusion, RED-CELL STORAGE, BLOOD-TRANSFUSION, STORED-BLOOD, TRANSPLANTATION, INCREASES, INFECTION
  • Bursa Uludag University Affiliated: Yes

Abstract

Introduction: Some immunologic changes in the recipient derived by allogeneic blood transfusion (ABT) are called Transfusion Related Immune Modulation (TRIM). Despite the exact mechanisms of these changes are not known, it is thought that ABT causes a decrease of CD4/CD8 ratio in the recipient. This study aimed to determine the CD4/CD8 ratio in stored erythrocyte suspensions (ES) and to obtain new information about TRIM mechanisms.