Serum leptin and ghrelin levels in response to methylprednisolone injection in healthy dogs.

Yilmaz Z., Ilcol Y. O., Golcu E.

Research in veterinary science, vol.82, no.2, pp.187-94, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 82 Issue: 2
  • Publication Date: 2007
  • Doi Number: 10.1016/j.rvsc.2006.07.005
  • Journal Name: Research in veterinary science
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.187-94
  • Keywords: leptin, ghrelin, glucocorticoid, methylprednisolone, dog, TERM SECRETORY REGULATION, GROWTH-HORMONE, PLASMA LEPTIN, ACTIVE FORM, OBESE GENE, CORTISOL, INSULIN, GLUCOCORTICOIDS, DEXAMETHASONE, ADIPOSITY
  • Bursa Uludag University Affiliated: Yes

Abstract

The aim of this study was to investigate the effects of methylprednisolone treatment on serum leptin and ghrelin levels in healthy dogs (n = 40). After 14 h of fasting, the dogs were injected intramuscularly with saline (control group) or methylprednisolone (1, 5 or 10 mg/ kg). Blood samples were collected prior to (baseline) and 2, 3, 4, 8, 12 and 24 h subsequent to the treatments. Serum leptin and ghrelin were measured by radioimmunoassay.