Mannose-Binding Lectin Levels in Late-Onset Sepsis in Preterm Infants: Results from a Prospective Study in a Tertiary Care Center

Dogan P., ÖZKAN H., Koksal N., ORAL H. B., ÇELEBİ S., Bagci O., ...More

FETAL AND PEDIATRIC PATHOLOGY, vol.39, no.5, pp.363-372, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.1080/15513815.2019.1652374
  • Journal Name: FETAL AND PEDIATRIC PATHOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE
  • Page Numbers: pp.363-372
  • Keywords: Late-onset sepsis, mannose binding lectin, preterm, NEONATAL SEPSIS, GENE POLYMORPHISM, SERUM-LEVELS, MBL LEVELS, RISK, INFECTION, SUSCEPTIBILITY, DEFICIENCY, NEWBORNS
  • Bursa Uludag University Affiliated: Yes

Abstract

Introduction: This study aimed to determine the association between serum mannose-binding lectin (MBL) levels, gene polymorphisms and late-onset sepsis (LOS) in preterm infants. Methods: Infants with <37 gestational weeks were categorized into two groups according to the presence of LOS during their hospitalization. An MBL level <700 ng/ml was defined as deficiency, MBL2 gene were analyzed. Results: Overall, 153 preterm infants were included. MBL deficiency was found to be more common in the LOS group (p = 0.02). The rate of Gram-negative sepsis was higher in MBL2 variant-type (p = 0.01). In the logistic regression analysis, MBL levels <700 ng/ml were found to have a significant effect on LOS development (odds ratio: 2.692, 95% confidence interval 1.196-5.8, p = 0.02). Conclusions: MBL deficiency is an important risk factor for the development of LOS. Furthermore, there is an association between MBL2 gene polymorphism and Gram-negative sepsis.