Effect of low-dose methyl prednisolone on serum cytokine levels following extracorporeal circulation

Yilmaz M., Ener S., Akalin H., Sagdic K., Serdar O., Cengiz M.

PERFUSION-UK, vol.14, no.3, pp.201-206, 1999 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 3
  • Publication Date: 1999
  • Doi Number: 10.1177/026765919901400308
  • Journal Name: PERFUSION-UK
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.201-206


The systemic inflammatory response to cardiopulmonary bypass (CPB) is associated with increased production of cytokines. This systemic inflammatory response characterized by the activation of interleukin-6 (IL-6) and interleukin-8 (IL-8) during and after CPB is well documented. A prospective, randomized, double-blind study was performed so as to understand the effects of low-dose methyl prednisolone sodium succinate (MPSS) on the circulating levels of serum cytokines and clinical outcome.