Lack of chromosomal aberrations in patients with goiter and iodine deficiency

Gulten T., TARIM Ö. F., ERCAN İ.

International Pediatrics, cilt.17, sa.2, ss.90-93, 2002 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 2
  • Basım Tarihi: 2002
  • Dergi Adı: International Pediatrics
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.90-93
  • Anahtar Kelimeler: Chromosome aberrations, Genetic, Goiter, Iodine deficiency, Radiation
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Iodine deficiency increases iodine uptake of the thyroid gland and the incidence of goiter. Therefore, mutagenic effects and chromosomal aberrations are expected if exposure to radioactive iodine occurs in an area of endemic iodine deficiency. In this investigation, we aimed to determine whether or not there is any mutagenic chromosomal damage in patients with goiter. Sister chromatid exchange (SCE) method was used as a cytogenetic investigation to observe the Deoxyribonucleic acid (DNA) damage of goiter patients at the chromosomal level.