Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey

ÖZBEK, Uğur; Sirma, S; Agaoglu, L; Yuksel, L; Anak, S; Yildiz, I; Devecioglu, O; Timur, C; Meral, A; Gedikoglu, G

doi:10.1097/00043426-200303000-00005

Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey

ÖZBEK U., Sirma S., Agaoglu L., Yuksel L., Anak S., Yildiz I., ...More

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, vol.25, no.3, pp.204-208, 2003 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 25 Issue: 3
Publication Date: 2003
Doi Number: 10.1097/00043426-200303000-00005
Journal Name: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.204-208
Bursa Uludag University Affiliated: No

Abstract

Purpose: The t(12;21) translocation is the most common reciprocal chromosomal rearrangement in pediatric acute lymphoblastic leukemia (ALL). This translocation fuses two genes, TEL and AML1, and results in the production of the TEL-AML1 fusion protein. The authors investigated the incidence and prognostic significance of the TEL-AML1 fusion gene in patients with ALL in Turkey.