Unfolded Protein Response is Involved in Trans-Platinum (II) Complex-Induced Apoptosis in Prostate Cancer Cells via ROS Accumulation

KARAKAŞ, DİDEM; Cevatemre, Buse; ORAL, ARZU; YILMAZ, VEYSEL; Ulukaya, Engin

doi:10.2174/1871520619666190409103334

Unfolded Protein Response is Involved in Trans-Platinum (II) Complex-Induced Apoptosis in Prostate Cancer Cells via ROS Accumulation

KARAKAŞ D., Cevatemre B., ORAL A., YILMAZ V. T., Ulukaya E.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.19, sa.9, ss.1184-1195, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 19 Sayı: 9
Basım Tarihi: 2019
Doi Numarası: 10.2174/1871520619666190409103334
Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1184-1195
Anahtar Kelimeler: Prostate cancer, cytotoxicity, apoptosis, oxidative stress, unfolded protein response, platinum(II) complex, ENDOPLASMIC-RETICULUM STRESS, HISTONE H2AX PHOSPHORYLATION, N-TERMINAL KINASE, OXIDATIVE STRESS, IN-VITRO, STRUCTURAL-CHARACTERIZATION, CRYSTAL-STRUCTURE, ER STRESS, DNA, DESIGN
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: Prostate cancer is one of the most common cancer types and it is the sixth leading cause of cancer-related death in men worldwide. Even though novel treatment modalities have been developed, it still a lifethreatening disease. Therefore novel compounds are needed to improve the overall survival.