Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells
NANOMEDICINE, cilt.12, sa.19, ss.2319-2333, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 19
- Basım Tarihi: 2017
- Doi Numarası: 10.2217/nnm-2017-0180
- Dergi Adı: NANOMEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2319-2333
- Anahtar Kelimeler: Ag2S quantum dots, cancer therapy, doxorubicin, near-infrared imaging, targeting, DRUG-DELIVERY, HIGHLY LUMINESCENT, CYTOTOXICITY, FOLATE, CARDIOTOXICITY, NANOPARTICLES, APOPTOSIS, ASSAY, TOOL
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
We aim to develop folic acid ( FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region. Materials & methods: Cationic Ag2S NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells. Results: Significantly higher uptake of DOX by human cervical carcinoma cells cells and a greater therapeutic effect along with a strong intracellular optical signal were obtained with DOX-loaded FA-conjugated Ag2S NIRQDs. Conclusion: These Ag2S NIRQDs are promising theranostic nanoparticles for receptor-mediated delivery of DOX with enhanced drug efficacy combined with optical imaging.