The association between cardiac valvular calcification and fetuin-A levels in kidney transplant recipients


Koca N., ERSOY A., Sensoy B., Kirhan E., Gullulu S., ERSOY C., ...More

CLINICAL AND EXPERIMENTAL NEPHROLOGY, vol.23, no.10, pp.1250-1256, 2019 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 10
  • Publication Date: 2019
  • Doi Number: 10.1007/s10157-019-01761-2
  • Journal Name: CLINICAL AND EXPERIMENTAL NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1250-1256
  • Keywords: Kidney transplantation, Valvular calcification, Fetuin A, VASCULAR CALCIFICATION, CARDIOVASCULAR MORTALITY, VALVE CALCIFICATION, CIRCULATING FETUIN, AORTIC-STENOSIS, DIALYSIS, SERUM, DISEASE, BIOMARKER, MECHANISMS

Abstract

Objectives Low fetuin-A levels in hemodialysis patients can be associated with development of vascular and valvular calcifications. The mechanisms underlying vascular and valvular calcifications are multifactorial. There are a few studies showing the relationship between low fetuin-A levels and valvular calcification after kidney transplantation. We aimed to evaluate the association between serum fetuin-A levels and valvular calcification in kidney transplant recipients. Methods The cardiac valvular calcification was assessed by echocardiography in 56 recipients. Patients were divided into two groups as those with (n = 11) and without (n = 45) aortic and/or mitral valve calcification. The extent of valvular calcification was visually assessed according to the standard visual score method: moderately (multiple larger spots) and heavily calcified (extensive thickening and calcification) of all cusps. Serum fetuin-A levels were measured. Results The demographic features of both groups were comparable. There was no significant difference between regular physical exercise (63.6% vs. 55.6%), obesity (18.2% vs. 17.8%), abdominal obesity (54.5% vs. 46.7%), smoking (0% vs. 13.3%), hypertension (63.6% vs. 68.9%), left ventricular hypertrophy (45.5% vs. 33.3%) and diabetes mellitus (9.1% vs. 20%) ratios in groups with or without valvular calcification, respectively (p > 0.05). Fetuin-A levels of both groups did not differ. Fetuin-A levels positively correlated with serum creatinine (r 0.326, p = 0.014), and negatively correlated with estimated glomerular filtration rate (r - 0.297, p = 0.026). Conclusions We could not find a relationship between serum fetuin-A levels and valvular calcification in kidney recipients. In this population, further studies are needed to assess the role of serum fetuin-A in valvular calcification.