PurposeTo evaluate the effectiveness of oxytocin infusion to reduce intraoperative bleeding during abdominal myomectomies.MethodsThis randomized, parallel group, blinded study was conducted between October 2017 and May 2018. Patients undergoing abdominal myomectomies were randomized 1:1 either to the oxytocin group or to the control group (saline). In the oxytocin group, 10IU oxytocin in 500ml of saline at a rate of 120ml/h was given during the course of the operation. The primary outcome of this study was to measure intraoperative blood loss between the study groups. Correlation and multiple regression analysis were performed to illustrate factors associated with intraoperative blood loss during the myomectomy.ResultsThe mean intraoperative blood loss during the surgery was 489.20239.72ml in the oxytocin group and was 641.40 +/- 288.21ml in the control group. The hemoglobin decline was more evident in the control group than in the oxytocin group. Positive correlations were also observed between the intraoperative blood loss and number of fibroids removed during the surgery, largest fibroid removed and weight of fibroids removed. The use of oxytocin infusion during the myomectomy resulted in a reduction of bleeding in the regression model.ConclusionIntravenous oxytocin infusion is a safe and practical method to reduce intraoperative blood oss during the abdominal myomectomy.