Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release

Ulus I. H., Watkins C. J., Cansev M., Wurtman R. J.

CELLULAR AND MOLECULAR NEUROBIOLOGY, cilt.26, ss.563-577, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1007/s10571-006-9004-5
  • Dergi Adı: CELLULAR AND MOLECULAR NEUROBIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.563-577
  • Anahtar Kelimeler: cytidine, uridine, choline, phospholipid synthesis, acetylcholine release, CDP-choline, RAT STRIATUM, SLICES, BIOSYNTHESIS, STIMULATION, CELLS
  • Bursa Uludağ Üniversitesi Adresli: Hayır

Özet

Aims: Treatments that increase acetylcholine release from brain slices decrease the synthesis of phosphatidylcholine by, and its levels in, the slices. We examined whether adding cytidine or uridine to the slice medium, which increases the utilization of choline to form phospholipids, also decreases acetylcholine levels and release.