Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release


Ulus I. H. , Watkins C. J. , Cansev M. , Wurtman R. J.

CELLULAR AND MOLECULAR NEUROBIOLOGY, vol.26, pp.563-577, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26
  • Publication Date: 2006
  • Doi Number: 10.1007/s10571-006-9004-5
  • Title of Journal : CELLULAR AND MOLECULAR NEUROBIOLOGY
  • Page Numbers: pp.563-577
  • Keywords: cytidine, uridine, choline, phospholipid synthesis, acetylcholine release, CDP-choline, RAT STRIATUM, SLICES, BIOSYNTHESIS, STIMULATION, CELLS

Abstract

Aims: Treatments that increase acetylcholine release from brain slices decrease the synthesis of phosphatidylcholine by, and its levels in, the slices. We examined whether adding cytidine or uridine to the slice medium, which increases the utilization of choline to form phospholipids, also decreases acetylcholine levels and release.