Akademik Veri Yönetim Sistemi
East Black Sea Journal of Health Sciences, cilt.2, sa.Kongre özel sayısı, ss.91-101, 2023 (Hakemli Dergi)
ABSTRACT
Aim: Toluene is the most preferred organic solvent. Prolonged exposure to toluene, causes serious health problems. The International Agency for Research on Cancer (IARC) has classified toluene as "possibly carcinogenic to humans" (Group 2B). This classification states that toluene may have potential carcinogenic effects. Toluene exposure has been linked to the formation of reactive nitrogen species and reactive oxygen species, resulting in direct tissue damage and alteration of various antioxidant systems. Resveratrol, which has a polyphenol structure, is a molecule that has important effects on plants. It is known to have positive effects on humans as well. In this study, the effect of exposure to toluene on nitric oxide production, which has an important role as a biological regulator in cardiovascular, neurological, immunological and many other systems, and the protective properties of resveratrol were investigated.
Materials and Methods: While 900mg/kg dose of toluene was administered intraperitoneally to male rats (250-350gr Wistar-Albino), 5, 10 and 20mg/kg doses of resveratrol were administered the same way for six days. Nitric oxide levels and Nitric oxide synthase activities were investigated in liver tissue and serum.
Findings: The data showed an increased nitric oxide level in the liver tissue and serum and a high nitric oxide synthase activity following toluene administration. Significant reductions in nitric oxide levels and nitric oxide synthase activity in the liver were observed after the administration of various dosages of resveratrol.
Results: Our results suggested that high doses of toluene induce nitric oxide production, whereas resveratrol possesses protective properties.
Keywords: Toluene, resveratrol, nitric oxide, nitric oxide synthase