Role of intracerebroventricular vasopressin in the development of stress-induced gastric lesions in rats

Buyukcoskun N., Ozluk K.

PHYSIOLOGICAL RESEARCH, cilt.48, sa.6, ss.451-455, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 6
  • Basım Tarihi: 1999
  • Dergi Adı: PHYSIOLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.451-455
  • Anahtar Kelimeler: vasopressin, restraint-cold stress, gastric mucosal lesions, vasopressin V-1 receptor antagonist, CORTICOTROPIN-RELEASING FACTOR, ACID SECRETION, RESTRAINT, ULCER
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

We investigated whether arginine vasopressin (AVP) has a central influence on the development of gastric mucosal lesions evoked by restraint-cold stress in rats. AVP and vasopressin V-1 receptor antagonist were injected intracerebroventricularly (icv) and the rats were exposed to restraint-cold stress for five hours. After decapitation the stomachs were examined for gastric mucosal lesions which were evaluated according to an ulcer score. Three different doses of AVP and V-1 receptor antagonist were administered in order to investigate the effects of extogenous and endogenous AVP on stress-induced gastric mucosal lesions. The intensity of gastric mucosal lesions was reduced when exogenous AVP was injected intracerebroventricularly. On the other hand, vasopressin V-1 receptor antagonist, which was administered by the same route, augmented gastric mucosal lesions. Our findings indicate that AVP, injected centrally, plays a role in preventing the formation of gastric mucosal lesions induced by stress via a central V-1 receptor.