Modulation of gamma-glutamyl transpeptidase activity by dietary eicosapentaenoic acid and vitamin E in livers of rabbits on hypercholesterolemic diet

Eryurek F., Surmen E., Omer B., Altug T., Oner P., Deniz G.

Research Communications in Chemical Pathology and Pharmacology, vol.65, no.3, pp.389-393, 1989 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 3
  • Publication Date: 1989
  • Journal Name: Research Communications in Chemical Pathology and Pharmacology
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.389-393


Rabbits were fed high-cholesterol diets containing either eicosapentaenoic acid (EPA) or vitamin E at doses of 80 mg and 100 IU per day, respectively. Liver gamma-glutamyl transpeptidase (GGT) activity and liver cholesterol and phospholipid levels were determined following the administration of the diets for 45 days. The feeding of cholesterol produced the highest concentrations of cholesterol in livers accompanied with the elevated enzymatic activity. Addition of EPA to the diet dramatically reduced GGT activity to normal levels, whereas vitamin E administration caused only a slight reduction.