Akademik Veri Yönetim Sistemi
Journal of Drug Delivery Science and Technology, cilt.119, 2026 (SCI-Expanded, Scopus)
This study reports the fabrication and characterization of polycaprolactone/pullulan nanofiber mats incorporating black seed oil (PCL/PUL-BSO) for potential biomedical applications. The PCL/PUL-BSO nanofiber mats with varying PCL/PUL ratios (1:1, 1:2, and 1:3) were produced by electrospinning, and their morphology, physicochemical properties, swelling, degradation, thermal stability, and drug release behavior were systematically investigated. Increasing PUL content enhanced hydrophilicity, swelling ratio, and degradation rate, primarily due to increased water uptake and reduced intermolecular interactions within the polymer matrix. BSO incorporation significantly affected the properties of the mats. Drug release studies revealed distinct release profiles depending on PCL/PUL ratios: 1:1 mats favored sustained, low-dose release (53.9 ± 3.3% over 44 days), 1:2 mats exhibited a balanced profile with a moderate initial burst (23.9 ± 2.8 % in 6 h) and prolonged delivery (63.4 ± 5.0% over 44 days), and 1:3 mats supported rapid and high-extent release (87.2 ± 2.1% over 44 days). The PCL/PUL-BSO (1:2) nanofiber mat with fiber diameters of 409 ± 53 nm exhibited balanced swelling and degradation properties, making the mat suitable for medium-term biomedical applications. DSC and TGA analyses confirmed the compatibility of BSO with the polymer matrix and thermal stability under sterilization conditions. Consequently, BSO incorporation ensured well-balanced hydrophilicity, porosity, permeability, and mechanical strength, leading to a nanofiber mat with outstanding properties and excellent promise for biomedical use.