The differential anticancer effects of green tea in estrogen receptor-positive and estrogen receptor-negative human breast cancer cell lines


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Arı F. , Ulukaya E., Yılmaztepe Oral A. , Özel M. Z. , Kutlular Ö.

Advances in Molecular Medicine, vol.3, no.2, pp.69-75, 2007 (Refereed Journals of Other Institutions)

  • Publication Type: Article / Article
  • Volume: 3 Issue: 2
  • Publication Date: 2007
  • Doi Number: 10.2399/amm.07.069
  • Title of Journal : Advances in Molecular Medicine
  • Page Numbers: pp.69-75

Abstract

Green tea components exert many biological effects, including antitumor and cancer preventive activities. In the search for breast cancer, the effects of green tea extract (GTE) were tested on the estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) human breast cancer cell lines. The growth inhibition by GTE was tested by the MTT assay in which the number of alive cells is proportional to the amount of formazan produced by the cells, which is measured by ELISA. GTE treatment resulted in a dose-dependent inhibition of cell growth in MDA-MB-231 cell line. However it did not show any inhibition effect in MCF-7 cell line. GTE further increased the cytotoxic activity of classical FEC treatment at the lowest doses in MDA-MB-231 cell line. However, as contrast, it diminished the effect of FEC treatment in MCF-7 cell line. These findings suggest that the effect of green tea depends on the estrogen-receptor status of the breast cancer cell line.