A patient with tyrosine kinase 2 deficiency without hyper-IgE syndrome.

Kilic S. Ş., Hacimustafaoglu M. K., Boisson-Dupuis S., Kreins A. Y., Grant A. V., Abel L., ...More

The Journal of pediatrics, vol.160, no.6, pp.1055-7, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 160 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1016/j.jpeds.2012.01.056
  • Journal Name: The Journal of pediatrics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1055-7
  • Bursa Uludag University Affiliated: Yes


We describe a Turkish patient with tyrosine kinase 2 deficiency who suffered from disseminated Bacille Calmette-Guerin infection, neurobrucellosis, and cutaneous herpes zoster infection. Tyrosine kinase 2 deficiency should be considered in patients susceptible to herpes viruses and intramacrophage pathogens even in the absence of atopy, high serum IgE, and staphylococcal disease. (J Pediatr 2012; 160:1055-7)