Adiponectin and IGF-1 are negative acute phase proteins in a dog model of acute endotoxaemia


Tvarijonaviciute A., Eralp O., KOCATÜRK M., YILMAZ Z., Ceron J. J.

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol.140, pp.147-151, 2011 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 140
  • Publication Date: 2011
  • Doi Number: 10.1016/j.vetimm.2010.11.011
  • Journal Name: VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.147-151
  • Keywords: Adiponectin, CRP, Hp, Dog, Endotoxaemia, IGF-1, EXPRESSION, INFLAMMATION, DECREASE, CHOLINE, INJURY

Abstract

The objective of this study was to evaluate the influence of an experimentally induced acute inflammation on serum adiponectin and insulin-like growth factor 1 (IGF-1) levels in the dog, and to compare their evolution with other well-established acute phase proteins (APPs) such as C-reactive protein (CRP), and haptoglobin (Hp). Therefore levels of adiponectin, IGF-1 and a profile of APPs were measured in healthy dogs after intravenous administration of E. coli LPS (0.02 mg/kg) and compared with dogs injected with saline solution (0.2 mL/kg). Adiponectin and IGF-1 were both decreased in response to endotoxins in the dog. Significant positive correlations were found between adiponectin and IGF-1 (r = 0.31; p < 0.05). Adiponectin had also a significant negative correlation with CRP (r = 0.39; p < 0.05) and Hp (r = -0.27; p < 0.05), whereas IGF-1 had significant negative correlation with CRP (r = -0.52; p < 0.001).