Serum CCL-18 level is a risk factor for COPD exacerbations requiring hospitalization.
International journal of chronic obstructive pulmonary disease, cilt.12, ss.199-208, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12
- Basım Tarihi: 2017
- Doi Numarası: 10.2147/copd.s118424
- Dergi Adı: International journal of chronic obstructive pulmonary disease
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.199-208
- Anahtar Kelimeler: COPD, frequent exacerbator, hospitalized exacerbation, PARC/(CCL-18), OBSTRUCTIVE PULMONARY-DISEASE, SYSTEMIC INFLAMMATION, LUNG-FUNCTION, BIOMARKERS, FREQUENCY, CCL18, MACROPHAGES, VALIDATION, PHENOTYPES, DYSPNEA
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
Introduction: Chemokine (C-C motif) ligand 18 (CCL-18) has been shown to be elevated in chronic obstructive pulmonary disease (COPD) patients. This study primarily aimed to evaluate whether the serum CCL-18 level differentiates the frequent exacerbator COPD phenotype from infrequent exacerbators. The secondary aim was to investigate whether serum CCL-18 level is a risk factor for exacerbations requiring hospitalization.