Acute colchicine intoxication during clarithromycin administration in patients with chronic renal failure

Akdag I., Ersoy A., Kahvecioglu S., Gullulu M., Dilek K.

JOURNAL OF NEPHROLOGY, cilt.19, sa.4, ss.515-517, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 4
  • Basım Tarihi: 2006
  • Dergi Adı: JOURNAL OF NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.515-517
  • Anahtar Kelimeler: chronic renal failure, colchicine toxicity, clarithromycin, peritoneal dialysis, familial Mediterranean fever, gout, OVERDOSE, TOXICITY
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Colchicine is an effective antiinflammatory medication. It should be used with great caution, however, in patients requiring dialysis. Coadministration of colchicine and macrolides may impair colchicine elimination, resulting in excess drug exposure and toxicity. We report 2 renal failure cases of colchicine intoxication occurring with the administration of clarithromycin.