Acute colchicine intoxication during clarithromycin administration in patients with chronic renal failure

Akdag I., Ersoy A., Kahvecioglu S., Gullulu M., Dilek K.

JOURNAL OF NEPHROLOGY, vol.19, no.4, pp.515-517, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2006
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.515-517
  • Keywords: chronic renal failure, colchicine toxicity, clarithromycin, peritoneal dialysis, familial Mediterranean fever, gout, OVERDOSE, TOXICITY
  • Bursa Uludag University Affiliated: Yes


Colchicine is an effective antiinflammatory medication. It should be used with great caution, however, in patients requiring dialysis. Coadministration of colchicine and macrolides may impair colchicine elimination, resulting in excess drug exposure and toxicity. We report 2 renal failure cases of colchicine intoxication occurring with the administration of clarithromycin.