Mn(OAc)(3) Induced C-4 Arylations of Quinazoline 3-Oxides with Arylboronic Acids

Samandram R., Korukcu M. C. , COŞKUN N.

SYNTHESIS-STUTTGART, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2021
  • Doi Number: 10.1055/a-1577-6344
  • Title of Journal : SYNTHESIS-STUTTGART
  • Keywords: quinazoline, quinazoline 3-oxide, C-H activation, arylation, arylboronic acids, C-H ACTIVATION, N-OXIDES, QUINOLINE, FUNCTIONALIZATION, AMINATION, ACCESS


The use of manganese triacetate as an oxidant component in the C-4 arylations of 2-aryl-quinazoline 3-oxides with arylboronic acids- is reported. The new protocol was applied to prepare new 2,4-di-arylated quinazoline 3-oxides in good to high yields. The method was shown to tolerate various substituents on both aromatic rings, and no complications such as deoxygenation or rearrangement to quinazolin-4(3H)-one was observed.