Evaluation of TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms in Turkish patients with tuberculosis

Ceylan E., Karkucak M., Coban H., KARADAĞ M., Yakut T.

JOURNAL OF INFECTION AND PUBLIC HEALTH, cilt.10, sa.6, ss.774-777, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.jiph.2016.11.003
  • Dergi Adı: JOURNAL OF INFECTION AND PUBLIC HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.774-777
  • Anahtar Kelimeler: Tuberculosis, Gene polymorphism, Mannose-binding lectin, Tumor necrosis factor-alpha, MANNOSE-BINDING LECTIN, CONFERS PROTECTION, HEPATITIS-B, ASSOCIATION, SUSCEPTIBILITY, CHILDREN, IL-10, INTERLEUKIN-10, METAANALYSIS, MENINGITIS
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Objective: MBL acts as a binding protein that enables uptake of mycobacteria into macrophages. And, TNF-alpha is an important cytokine that is involved in control of mycobacterial infections both in-vivo and in-vitro. A large number of genetic factors exerting susceptibility to tuberculosis has been identified, among which mannose-binding lectin and tumor necrosis factor-alpha call attention. The objective of this study is to compare the frequency of TNF-alpha and MBL gene polymorphisms between patients diagnosed with tuberculosis and healthy volunteers in Turkey, and determine the association between tuberculosis and TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms.