Evaluation of TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms in Turkish patients with tuberculosis


Ceylan E., Karkucak M., Coban H., KARADAĞ M. , Yakut T.

JOURNAL OF INFECTION AND PUBLIC HEALTH, vol.10, no.6, pp.774-777, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1016/j.jiph.2016.11.003
  • Title of Journal : JOURNAL OF INFECTION AND PUBLIC HEALTH
  • Page Numbers: pp.774-777
  • Keywords: Tuberculosis, Gene polymorphism, Mannose-binding lectin, Tumor necrosis factor-alpha, MANNOSE-BINDING LECTIN, CONFERS PROTECTION, HEPATITIS-B, ASSOCIATION, SUSCEPTIBILITY, CHILDREN, IL-10, INTERLEUKIN-10, METAANALYSIS, MENINGITIS

Abstract

Objective: MBL acts as a binding protein that enables uptake of mycobacteria into macrophages. And, TNF-alpha is an important cytokine that is involved in control of mycobacterial infections both in-vivo and in-vitro. A large number of genetic factors exerting susceptibility to tuberculosis has been identified, among which mannose-binding lectin and tumor necrosis factor-alpha call attention. The objective of this study is to compare the frequency of TNF-alpha and MBL gene polymorphisms between patients diagnosed with tuberculosis and healthy volunteers in Turkey, and determine the association between tuberculosis and TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms.