Evaluation of TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms in Turkish patients with tuberculosis

Ceylan E., Karkucak M., Coban H., KARADAĞ M., Yakut T.

JOURNAL OF INFECTION AND PUBLIC HEALTH, vol.10, no.6, pp.774-777, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1016/j.jiph.2016.11.003
  • Journal Name: JOURNAL OF INFECTION AND PUBLIC HEALTH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.774-777
  • Keywords: Tuberculosis, Gene polymorphism, Mannose-binding lectin, Tumor necrosis factor-alpha, MANNOSE-BINDING LECTIN, CONFERS PROTECTION, HEPATITIS-B, ASSOCIATION, SUSCEPTIBILITY, CHILDREN, IL-10, INTERLEUKIN-10, METAANALYSIS, MENINGITIS
  • Bursa Uludag University Affiliated: Yes

Abstract

Objective: MBL acts as a binding protein that enables uptake of mycobacteria into macrophages. And, TNF-alpha is an important cytokine that is involved in control of mycobacterial infections both in-vivo and in-vitro. A large number of genetic factors exerting susceptibility to tuberculosis has been identified, among which mannose-binding lectin and tumor necrosis factor-alpha call attention. The objective of this study is to compare the frequency of TNF-alpha and MBL gene polymorphisms between patients diagnosed with tuberculosis and healthy volunteers in Turkey, and determine the association between tuberculosis and TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms.