Double Heteroatom Functionalization of Arenes Using Benzyne Three-Component Coupling
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, cilt.54, sa.7, ss.2156-2159, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 54 Sayı: 7
- Basım Tarihi: 2015
- Doi Numarası: 10.1002/anie.201410751
- Dergi Adı: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2156-2159
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
Arynes participate in three-component coupling reactions with N, S, P, and Se functionalities to yield 1,2-heteroatom-difunctionalized arenes. Using 2-iodophenyl aryl-sulfonates as benzyne precursors, we could effectively add magnesiated S-, Se-, and N-nucleophilic components to the strained triple bond. In the same pot, addition of electrophilic N, S, or P reagents and a copper(I) catalyst trapped the intermediate aryl Grignard to produce a variety of 1,2-difunctionalized arenes.