Akademik Veri Yönetim Sistemi
39. Ulusal Nefroloji Kongresi, Antalya, Türkiye, 9 - 13 Kasım 2022
Aim
Autosomal dominant polycystic kidney disease (ADPKD) of adulthood can affect all tissues, especially renal tubular epithelial cells, by altering the expression of many intracellular proteins as a result of mutations in ciliary proteins. Decreased 5' AMP-activated protein kinase (AMPK) activity in the cell is one of the most important features of the disease, and drugs that increase AMPK activity are used for treatment. Irisin, a newly identified muscle protein, is a myokine formed as a result of AMPK activation from fibronectin-type III domain-containing protein 5 (FNDC5) and is negatively correlated with oxidative stress and inflammation. In this study, irisin levels in early-stage ADPKD were compared with those in the healthy control group.
Methods
A total of 38 early-stage ADPKD patients and 38 healthy controls were enrolled in the study. All patients were selected from those with a positive family history and entered into the Turkish Society of Nephrology Cystic Kidney Disease Study Group Data Sheet. Patients with GFR-EPI less than 60 ml/min and patients with active infection were excluded from the study.
Results
Irisin levels (ng/ml) were found to be significantly lower in patients with ADPKD compared to healthy controls (p < 0.001) (Table 1). In addition, irisin levels in ADPKD were found to correlate inversely with blood urea nitrogen (BUN, mg/dL) and creatinine (mg/dl), while showing a significant positive correlation with glomerular filtration rate (GFR, ml/min).