Overexpression of the Long Noncoding RNA HomeoboxA Transcript at the Distal Tip Predicts Poor Prognosis in a KRAS-Independent Manner in Periampullary Region Tumors


Balcin O., AKSOY S., TUNCA B., KAYA E., EGELİ Ü., Tezcan G., ...More

PANCREAS, vol.47, no.2, pp.213-220, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.1097/mpa.0000000000000984
  • Journal Name: PANCREAS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.213-220
  • Keywords: LncRNA, HOTTIP, KRAS, periampullary region tumors, prognosis, PANCREATIC DUCTAL ADENOCARCINOMA, CANCER, HOTTIP, HOTAIR, PROGRESSION, CHROMATIN, METASTASIS, EXPRESSION, BIOMARKERS, EVOLUTION
  • Bursa Uludag University Affiliated: Yes

Abstract

Objectives: Periampullary region tumors (PRTs) are the fifth highest cause of cancer-related deaths worldwide. Although recent studies have highlighted the prognostic value of the long noncoding RNA HomeoboxA transcript at the distal tip (HOTTIP) in patients with pancreatic ductal adenocarcinoma, the relationship between HOTTIP and clinical outcome of all PRTs remains obscure. The aim of this study was to clarify the prognostic significance of HOTTIP in patients with all PRTs related to KRAS mutational status.