Palladium (II) Complex Enhances ROS-Dependent Apoptotic Effects via Autophagy Inhibition and Disruption of Multiple Signaling Pathways in Colorectal Cancer Cells

Aydinlik S., Erkisa M., Ari F., Celikler S., Ulukaya E.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.21, sa.6, ss.1284-1291, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 6
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1871520620666200929153804
  • Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1284-1291
  • Anahtar Kelimeler: Apoptosis, autophagy, metal-based compounds, ROS, colorectal cancer, chloroquine, PLATINUM(II) SACCHARINATE COMPLEXES, COLON-CANCER, CYTOTOXIC ACTIVITY, IN-VITRO, 5-FLUOROURACIL, CHLOROQUINE, CHEMOTHERAPY, BEVACIZUMAB, COMBINATION, ACTIVATION
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: Inhibition of autophagy is reported to be a therapeutically effective strategy in overcoming resistance that is a deadly outcome in cancer. One of the most common reasons for chemo-resistance to treatment is the patients with tumors exhibiting a KRAS mutation, which occurs in approximately 40% of colorectal cancer patients.