Impact of 3'UTR variation patterns of the KRAS gene on the aggressiveness of pancreatobiliary tumors with the KRAS G13D mutation in a Turkish population.

EGELİ, ÜNAL; Ak, SEÇİL; ÇEÇENER, GÜLŞAH; TUNCA, BERRİN; Tezcan, GÜLÇİN; Sevinc, Elif; KAYA, EKREM; DÜNDAR, HALİT; Sarkut, Pinar; ÖZEN, YILMAZ; Balcin, Ozkan; EVRENSEL, TÜRKKAN; YERCİ, ÖMER; UĞRAŞ, NESRİN

doi:10.1016/j.pan.2016.05.004

Impact of 3'UTR variation patterns of the KRAS gene on the aggressiveness of pancreatobiliary tumors with the KRAS G13D mutation in a Turkish population.

EGELİ Ü., Ak S., ÇEÇENER G., TUNCA B., Tezcan G., Sevinc E. D., ...Daha Fazla

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], cilt.16, sa.4, ss.677-86, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 16 Sayı: 4
Basım Tarihi: 2016
Doi Numarası: 10.1016/j.pan.2016.05.004
Dergi Adı: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.677-86
Anahtar Kelimeler: KRAS, 3' untranslated region, Codon 13, Mutation, Invasion, K-RAS GENE, CANCER, PANCREAS, CODON-12, POLYMORPHISM, EXPRESSION, CARCINOMA, P53, ADENOCARCINOMA, MICRORNAS
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Objective: Several studies have demonstrated the importance of mutations in codons 12, 13 and 61 and variations in the 3' untranslated region (3'UTR) of the ICRAS gene, frequently observed genetic events in the progression of pancreatobiliary tumors (PBT). However, limited data exist on the clinical effect of these alterations. The aim of the current study was to clarify the frequency of relevant alterations of the 3'UTR regions of the KRAS gene and the effect of KRAS 3'UTR polymorphisms on the prognosis of patients with codon 12, 13 and 61 mutations in a Turkish population with PBT.