The association between hematologic parameters and intracranial injuries in pediatric patients with traumatic brain injury Running title: Haematologic parameters in paediatric head trauma


Eser P., Corabay S., ÖZMARASALI A. İ. , OCAKOĞLU G., TAŞKAPILIOĞLU M. Ö.

BRAIN INJURY, vol.36, no.6, pp.740-749, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 6
  • Publication Date: 2022
  • Doi Number: 10.1080/02699052.2022.2077442
  • Journal Name: BRAIN INJURY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, BIOSIS, CINAHL, EMBASE, Linguistics & Language Behavior Abstracts, MEDLINE, Psycinfo
  • Page Numbers: pp.740-749
  • Keywords: Glasgow coma score, hematologic markers, neurosurgery, outcome, pediatric patients, traumatic brain injury, GLASGOW COMA SCALE, CELL DISTRIBUTION WIDTH, TO-LYMPHOCYTE RATIO, COMPUTED-TOMOGRAPHY, RADIATION-EXPOSURE, MOTOR SCORE, NEUTROPHIL, MILD, ANEMIA, MANAGEMENT
  • Bursa Uludag University Affiliated: Yes

Abstract

Objective Analyzing the association between hematologic parameters and abnormal cranial computerized tomography (CT) findings after head trauma. Material and methods A total of 287 children with isolated traumatic brain injury (TBI) were divided into the 'normal' (NG), 'linear fracture' (LFG) and 'intraparenchymal injury' groups (IPG) based on head CT findings. Demographical/clinical data and laboratory results were obtained from medical records. Results The neutrophil-lymphocyte ratio was markedly higher in the LFG (p = 0.010 and p = 0.016, respectively) and IPG (p = 0.004 and p < 0.001, respectively) compared with NG. Lower lymphocyte-monocyte ratio (p = 0.044) and higher red cell distribution width-platelet ratio (RPR) (p = 0.030) were associated with intraparenchymal injuries. Patients requiring neurosurgical intervention had higher neutrophil-lymphocyte ratio (p = 0.026) and RPR values (p = 0.031) and lower platelet counts (p = 0.035). Lower levels of erythrocytes (p = 0.005), hemoglobin (p = 0.003) and hematocrit (p = 0.002) were associated with severe TBI and unfavorable outcome (p = 0.012, p = 0.004 and p = 0.006, respectively). Conclusions Hematologic parameters are useful in predicting the presence of abnormal cranial CT findings in children with TBI in association with injury severity; surgery need and clinical outcome.