Combination of Histone Deacetylase Inhibitor with Cu(II) 5,5-diethylbarbiturate Complex Induces Apoptosis in Breast Cancer Stem Cells: A Promising Novel Approach

Erkisa, Merve; Erkisa, Merve; Aztopal, Nazlihan; Aztopal, Nazlihan; Ertürk, ELİF; Erturk, Elif; Ulukaya, Engin; Ulukaya, Engin; Yilmaz, Veysel; Yılmaz, VEYSEL; Ari, FERDA; Arı, FERDA

doi:10.2174/1871520621666201207090702

Combination of Histone Deacetylase Inhibitor with Cu(II) 5,5-diethylbarbiturate Complex Induces Apoptosis in Breast Cancer Stem Cells: A Promising Novel Approach

Atıf İçin Kopyala

Erkisa M., Erkisa M., Aztopal N., Aztopal N., Ertürk E., Erturk E., ...Daha Fazla

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.21, sa.14, ss.1850-1860, 2021 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 21 Sayı: 14
Basım Tarihi: 2021
Doi Numarası: 10.2174/1871520621666201207090702
Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
Sayfa Sayıları: ss.1850-1860
Anahtar Kelimeler: Epigenetic modulators, valproic acid, Cu(II) complex, breast cancer stem cell, apoptosis, histone deacetylase inhibitor, COPPER COMPLEX, VALPROIC ACID, IN-VITRO, ANTICANCER ACTIVITY, DNA/BSA BINDING, METAL-COMPLEXES, DNA CLEAVAGE, ROS, PATHWAY, DIFFERENTIATION
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: Cancer Stem Cells (CSCs) are a subpopulation within the tumor that play a role in the initiation, progression, recurrence, resistance to drugs and metastasis of cancer. It is well known that epigenetic changes lead to tumor formation in cancer stem cells and show drug resistance. Epigenetic modulators and /or their combination with different agents have been used in cancer therapy.