Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line

Aydinlik S., Erkisa M., Cevatemre B., SARIMAHMUT M., DERE E., ARI F., ...Daha Fazla

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, cilt.1861, sa.2, ss.49-57, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1861 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.bbagen.2016.11.013
  • Dergi Adı: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.49-57
  • Anahtar Kelimeler: Autophagy, Breast cancer, Necroptosis, Drug resistance, Synergism, DOUBLE-EDGED-SWORD, INDUCED APOPTOSIS, PROTECTIVE AUTOPHAGY, DEATH, ACTIVATION, INDUCTION, CYCLE, HYDROXYCHLOROQUINE, MACROAUTOPHAGY, TUMORIGENESIS
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: The outcome of triple negative breast cancer is still poor and requires improvement with better therapy options. Autophagy has recently been shown to play a role in anticancer drug resistance. Therefore, we investigated if the effectiveness of doxorubicin was augmented by the inhibition of autophagy.