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Köse H., Eray Çamlı Ş., Turan S., Kılıç Gültekin S. Ş.

World Allergy Congress (WAC) in Istanbul, Türkiye, October 13-15, 2022., İstanbul, Turkey, 13 - 15 October 2022, vol.20, no.3, pp.98

  • Publication Type: Conference Paper / Full Text
  • Volume: 20
  • City: İstanbul
  • Country: Turkey
  • Page Numbers: pp.98
  • Bursa Uludag University Affiliated: Yes


Psychiatric Comorbidities in Pediatric Primary Immunodeficiency Patients

Hulya Kose1, Safak Eray2, Serkan Turan2, Sara Sebnem Kilic Gultekin1

1-Uludag University Faculty of Medicine, Department of Pediatric Immunology, Bursa, Turkey

2-Uludag University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Bursa, Turkey


Primary immunodeficiency diseases (PIDs) are a rare heterogeneous group of disorders of the immune system, including recurrent infections, autoimmunity, and malignancies. Therefore, such chronic disorders have a negative effect on psychological wellbeing, these negative outcomes may differ according to developmental period. We aimed to assess and compare emotional and behavioral problems among children and adolescents with PID.


Ninety-eight PID patients between the ages of 5-and 18 years enrolled in the study. The participants who were evaluated by blinded professionals completed a data form containing questions regarding sociodemographic and clinical features, The Strengths and Difficulties Questionnaire (SDQ), The Revised Child Anxiety and Depression Scale (RCADS), SNAP-IV Inattention and Hyperactivity/Impulsivity questionnaire were completed by the participants. The data were obtained from both child and parent.


The study sample consist of 98 children and adolescents, those 60(61.2%) female and 31 (38.8%) male. The mean age of patients was 12.23 ±6.06 years.

CVID (n=31. %21,6) and DGS (n=23, %23,5) were the most common PID’s in our cohort respectively. The most common psychiatric problems were reported to be peer relation problems (n=38, 38,8%) and emotional problems (n=24,24,5%) among the children with PID. The parents stated statistically higher emotional, behavioral(p=0.008) peer problems, (p=0.015), panic disorder (p=0.015), generalized anxiety disorder(p=0.031) in adolescents than in children, and the hyperactivity scores stated higher (p.0,003) in children than adolescents. According to self-report forms only peer relation problems (p=0.028) were stated higher in adolescents than children and there was not any significant difference between children and adolescents in terms of other emotional or behavioral problems.


PIDs affect both the physical and emotional functions of children and parents, which usually are a non-limited nature disease and had a role in the child’s overall life. The multidisciplinary care approach to PIDs may be helpful decrease the psychiatric stressors of children and their parents. Therefore, physicians may be helped by awareness of the major causes of emotional stress in PIDs.