Epigenetic approach to early-onset Parkinson's disease: low methylation status of SNCA and PARK2 promoter regions

ERYILMAZ I. E., ÇEÇENER G., Erer S., EGELİ Ü., TUNCA B., ZARİFOĞLU M., ...Daha Fazla

NEUROLOGICAL RESEARCH, cilt.39, sa.11, ss.965-972, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 11
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/01616412.2017.1368141
  • Dergi Adı: NEUROLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.965-972
  • Anahtar Kelimeler: Early-onset Parkinson's disease, epigenetic, methylation, SNCA, PARK2, ALPHA-SYNUCLEIN, LEUKOCYTE DNA, GENE, MUTATIONS, EXPRESSION
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background and aim: The effect of epigenetic modifications in the genes related to Parkinson's disease (PD) is still unclear. In the present study, we investigated methylation status of SNCA and PARK2 genes in patients with early-onset Parkinson's disease (EOPD).