Central sensitisation in primary Sjögren Syndrome and its effect on sleep quality.

Metin Ökmen B., Ayar K., Altan L., Yeşilöz Ö.

Modern rheumatology, vol.32, no.5, pp.908-914, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 5
  • Publication Date: 2022
  • Doi Number: 10.1093/mr/roab075
  • Journal Name: Modern rheumatology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.908-914
  • Keywords: Central sensitisation, pain, primary Sjogren Syndrome, sleep quality, NERVOUS-SYSTEM, NEUROPATHIC PAIN, FIBROMYALGIA, DISTURBANCES, PREVALENCE, SEVERITY, IMPACT
  • Bursa Uludag University Affiliated: Yes


Objective The aim of the present study is to evaluate the presence and frequency of central sensitisation (CS) in primary Sjogren Syndrome (pSS) and to determine the effect of CS on sleep quality. Materials and Methods In this cross-sectional study, 50 patients diagnosed with pSS between the ages of 18 and 75 were included. The healthy control group was composed of 43 healthcare workers. Each participant underwent a physical examination, and demographic data and the medications they used were recorded. Central sensitisation inventory and Pittsburgh Sleep Quality Index questionnaires were filled in to garner data on CS and sleep quality, respectively, from all participants. Results While central sensitisation inventory >40 was detected in 74% of pSS patients, it was 25.6% in healthy controls, and there is a statistically significant difference between the groups (p < .05). A correlation analysis of the central sensitisation inventory and Pittsburgh Sleep Quality Index values of all participants revealed a statistically significant correlation between all parameters other than the duration of sleep (p < .05). Conclusions CS was found to have a negative effect on sleep quality in patients with pSS. We suggest that the cause of widespread pain seen in patients with pSS as the possible development of CS should be considered.