The Role of the Dopamine beta-hydroxylase Functional Polymorphism in Patients with Early-Onset Parkinson's Disease in the Turkish Population


Erer S., ERYILMAZ I. E., Colak D. K., EGELİ Ü., ÇEÇENER G., TUNCA B., ...More

TURKISH JOURNAL OF NEUROLOGY, vol.27, no.1, pp.21-26, 2021 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.4274/tnd.2020.80633
  • Journal Name: TURKISH JOURNAL OF NEUROLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.21-26
  • Keywords: Early-onset Parkinson's disease, dopamine beta-hydroxylase (DBH), polymorphism, Turkish population
  • Bursa Uludag University Affiliated: Yes

Abstract

Objective: A functional single nucleotide polymorphism, rs1611115, in the dopamine beta-hydroxylase (DBH) gene, is reported to regulate plasma enzyme activity levels. Mere, we report the first evaluation of this association in patients with early-onset Parkinson's disease (EOPD) and healthy controls in the Turkish population.