Overexpression of CK20, MAP3K8 and EIF5A correlates with poor prognosis in early-onset colorectal cancer patients

TUNCA B., Tezcan G., ÇEÇENER G., EGELİ Ü., Zorluoglu A., Yilmazlar T., ...Daha Fazla

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, cilt.139, sa.4, ss.691-702, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 139 Sayı: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s00432-013-1372-x
  • Dergi Adı: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.691-702
  • Anahtar Kelimeler: Colorectal cancer, CK20, MAP3K8, EIF5A, Poor prognosis, Turkish population, INOSINE MONOPHOSPHATE DEHYDROGENASE, GENOMIC HYBRIDIZATION REVEALS, SQUAMOUS-CELL CARCINOMA, INDEPENDENT PREDICTOR, EXPRESSION, CYTOKERATIN-20, EIF-5A2, YOUNG, GENE, AGE
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Due to ethnic, genetic and environmental factors, the clinical and molecular characteristics of Turkish colorectal cancer (CRC) patients are different from those of Western populations. The aim of this study was to clarify the relevant alterations of gene expression associated with colorectal carcinogenesis in early-onset patients and to identify specific biomarkers that could provide novel therapeutic molecular targets in this population.