Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups


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Aksoy S. A., Yılmazlar T., Ercelik M., Tekin Ç., Uğraş N., Yerci Ö., ...More

Türk Kolon ve Rektum Hastalıkları Dergisi, vol.33, no.2, pp.43-47, 2023 (Peer-Reviewed Journal) identifier

Abstract

Aim: The risk of colorectal cancer development associated with low-grade dysplasia (LGD) and high-grade dysplasia (HGD) colon polyps at baseline polypectomy remains unclear. In this study, we investigated the role of microsatellite instability (MSI) in the formation and prognosis of dysplasia. Method: In the study, 40 polyps diagnosed as HGD, and 40 polyps diagnosed as LGD were evaluated according to the revised Vienna criteria (2015) as a result of polypectomy. MSI analysis was performed by fragment analysis using five different primers. Results: Three of the polyps diagnosed with LGD and eight of the polyps diagnosed with HGD turned into cancer during the follow-up period. The rate of MSI in sporadic colorectal dysplasia was determined as 36.3. A significant correlation was found between MSI status and polyp recurrence within the five-year follow-up period after polypectomy. Conclusion: In our study, it was determined that LGD and HGDs with MSI can recur, but polypectomy may be effective in preventing cancer formation in cases of dysplasia with MSI.