Comparison of Clinical and Molecular Wnt and SHH Subgroups in Medulloblastoma Tumor Cases.


Kaya I. S. , Aksoy S., Mutlu M., Tekin C., Taskapilioglu M. Ö. , Tunca B., ...More

Turkish neurosurgery, vol.31, no.4, pp.554-565, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.5137/1019-5149.jtn.32057-20.3
  • Journal Name: Turkish neurosurgery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.554-565
  • Keywords: Medulloblastoma, Wnt, SHH, Molecular diagnosis, EXPRESSION, GENE
  • Bursa Uludag University Affiliated: Yes

Abstract

AIM: To determine the Wnt and SHH subtypes at the molecular level, and to compare them clinically by examining the changes in CTNNB1, AXIN, PTCH1, SMO, SUFU, and GLI1 mRNA expression in the medulloblastoma of a Turkish population determined according to patient selection criteria. In this context, the clinical distinction between Wnt and SHH groups are realized by considering the age, gender, survival time, location of the lesion, and radiological features of the patients.