Comparison of Clinical and Molecular Wnt and SHH Subgroups in Medulloblastoma Tumor Cases.

Kaya I. S., Aksoy S., Mutlu M., Tekin C., Taskapilioglu M. Ö., Tunca B., ...Daha Fazla

Turkish neurosurgery, cilt.31, sa.4, ss.554-565, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5137/1019-5149.jtn.32057-20.3
  • Dergi Adı: Turkish neurosurgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.554-565
  • Anahtar Kelimeler: Medulloblastoma, Wnt, SHH, Molecular diagnosis, EXPRESSION, GENE
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

AIM: To determine the Wnt and SHH subtypes at the molecular level, and to compare them clinically by examining the changes in CTNNB1, AXIN, PTCH1, SMO, SUFU, and GLI1 mRNA expression in the medulloblastoma of a Turkish population determined according to patient selection criteria. In this context, the clinical distinction between Wnt and SHH groups are realized by considering the age, gender, survival time, location of the lesion, and radiological features of the patients.