CK19, CK20, EGFR and HER2 status of circulating tumor cells in patients with breast cancer

Tunca B., Egeli Ü., Çeçener G., Tezcan G., Gokgoz S., Tasdelen L., ...More

TUMORI JOURNAL, vol.98, no.2, pp.243-251, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 98 Issue: 2
  • Publication Date: 2012
  • Doi Number: 10.1700/1088.11937
  • Journal Name: TUMORI JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.243-251
  • Keywords: breast cancer, circulating tumor cells, prognosis, RNA-POSITIVE CELLS, POLYMERASE-CHAIN-REACTION, MAMMAGLOBIN MESSENGER-RNA, TRANSCRIPTION-PCR ASSAY, PERIPHERAL-BLOOD, COLORECTAL-CANCER, MOLECULAR-DETECTION, PROGNOSTIC VALUE, RT-PCR, ADJUVANT CHEMOTHERAPY
  • Bursa Uludag University Affiliated: Yes

Abstract

Aims and background. The major cause of death in breast cancer patients is metastasis. Various biomarkers have been used for the early detection of circulating tumor cells in the peripheral blood of breast cancer patients. The aims of the current study were to analyze circulating tumor cells in the blood of breast cancer patients by investigating EGFR, CK19, CK20 and HER2 expression profiles and to evaluate their prognostic importance.