The synthesis of single enantiomers of trans-alkene containing mycolic acids and related sugar esters

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Ali H. M., Koza G., Hameed R. T., Rowles R., Davies C., Al Dulayymi J. R., ...Daha Fazla

TETRAHEDRON, cilt.72, ss.7143-7158, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.tet.2016.08.089
  • Dergi Adı: TETRAHEDRON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.7143-7158
  • Anahtar Kelimeler: Mycolic acid, TDM, TMM, GMM, trans-Alkene, Trehalose monomycolate, Trehalose dimycolate, MYCOBACTERIUM-TUBERCULOSIS, CELL-WALL, CYCLOPROPANE SYNTHETASE, ORGANOCOPPER REAGENTS, HOMOLOGOUS SERIES, WAX ESTERS, BIOSYNTHESIS, SMEGMATIS, MONOMYCOLATE, VIRULENCE
  • Bursa Uludağ Üniversitesi Adresli: Hayır

Özet

Routes to single enantiomers of hydroxy, methoxy and ketomycolic acids containing an alpha-methyl-trans-alkene unit as well as related trehalose, glucose, arabinose and glycerol esters are described. In serodiagnostic assays to detect antibodies to mycobacterial lipids, the trehalose esters give higher responses to the serum of patients with culture positive tuberculosis than to that of culture negative patients. (C) 2016 Elsevier Ltd. All rights reserved.