Metallic magnesium: an efficient catalyst toward N-aryl and N-alkyl substituted amides directly from aliphatic carboxylic acids

Yildirim A.

MONATSHEFTE FUR CHEMIE, vol.146, no.6, pp.947-951, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 146 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.1007/s00706-014-1387-2
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.947-951
  • Keywords: Direct amidation, Amines, Carboxylic acids, Catalysis, Magnesium, ONE-POT, AMINES, CONVERSION, ESTERS, AMIDATION, ANILIDES, SURFACTANTS, ACYLATION, REAGENT
  • Bursa Uludag University Affiliated: Yes


An efficient and inexpensive procedure for direct conversion of aliphatic carboxylic acids into amides has been developed using anilines or aliphatic amines and Mg(0) as catalyst in toluene. The amides were obtained by single crystallization in moderate to excellent yields with high purity.